1500 Jheronimus Bosch paints the `Temptation of St. Antonius` as well as `Holy Antonius fire` victims with leg- and arm amputations. *** In his `Herbal Book`, botanic doctor Adam Lonitzer publishes the first exact description of `mutterkorn` (Claviceps purpurea) growing on grain and responsible for the epidemic `Ergotism` (1582) *** In central Europe healers & witches are wisdom-keepers of advanced herbal knowledge *** Johann VI. kindles up the witch hunt in Germany. Around Berlin 306 people in 20 villages are burnt to death.