1943 (April 19th) Dr. Hofmann deliberately ingests what he considers to be the smallest, most conservative amount of the compound LSD-25. 250 microgram, (a full trip). He commences to write laboratory notes after he notices the effect within an hour. But soon he can no longer write anything and decides to ride home on his bicycle. The effects then get much stronger and his trip becomes fully blown. Suffering great anxiety, he calls for the doctor. The next morning he feels unusually good, no hangover despite the profound effects – in fact, he writes `excellent physical & mental condition`. Within the next weeks the drug is tested by Dr. Hofmann`s colleagues, whom confirm his reactions. No substance yet known to mankind acts psychoactively in such infinitely small amounts.