1938 LSD-25 (the 25th compound in a series of semi-synthetic lysergic acid amides produced by a laboratory syntheses of ergot alkaloids, is formulated by Dr. Albert Hofmann at Sandoz Pharmaceutical Laboratories in Basel. Tested on laboratory animals it is making them `restless`. LSD-25 is not deemed sufficiently interesting to test further. (Other lysergic acid derivatives are proven useful obstetrics, geriatrics and the treatment of migraine headaches.)

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